The study will focus on important aspects related to follicle recruitment using exogenous gonadotropins in patients with polycystic ovaries: 1. Early follicle recruitment in patients with polycystic ovaries using corifollitropin alfa: does administration of this drug result in earlier and higher FSH (follicle stimulating hormone) concentrations above the threshold for follicle recruitment in an IVM (in vitro maturation) cycle preceded by oral contraceptive suppression, in comparison to normal daily administration of rFSH (recombinant follicle stimulating hormone, Puregon)?; 2. The maturation rate of the obtained oocyte-cumulus complexes in standard IVM media registered for clinical use: does stimulation with corifollitropin alfa versus recombinant FSH have an impact on the maturation rate and developmental capacity of the oocytes ?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
145
comparison between corifollitropin alfa and follitropin beta in IVM cycles
comparison between corifollitropin alfa and follitropin beta in IVM cycles
comparison between corifollitropin alfa and follitropin beta in IVM cycles
Single injection of 100 micrograms of corifollitropin alfa
Daily injection (three days) of follitropin beta
Daily administration of the oral contraceptive pill (Marvelon) for 21 days. Administration of the combined oral contraceptive pill will start after a blood test that demonstrates basal E2 levels and a negative serum hCG level.
UZ Brussel
Brussels, Belgium
Number of COC
Number of oocyte cumulus complexes obtained on the day of oocyte retrieval.
Time frame: 5 days after the first gonadotropin injection (on the day of oocyte retrieval)
Clinical pregnancy rate
Clinical pregnancy rate after the first embryo transfer following the IVM cycle
Time frame: At about 6 - 7 weeks gestation
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