Novel Evaluation With QGC001 in Hypertensive Overweight Patients of Multiple Ethnic Origins

Inclusion Criteria: * Subject must provide signed written informed consent; * Men and women greater than or equal to 18 years of age at Screening; * Diagnosis of primary (essential) hypertension (HTN) for at least 3 months prior to Screening and have an office SBP: * Between 145 mmHg and 170 mmHg at Screening and are treatment-naïve; or * Between 130 mmHg and 150 mmHg at Screening and are treated with less than or equal to 2 anti hypertensive medications. Anti-hypertensive medications must be stable for greater than or equal to 8 weeks prior to Screening; * SBP between 145 mmHg and 170 mmHg, inclusive, and DBP less than or equal to 105 mmHg at the Inclusion Visit after 2-week Run In Period; * Body mass index between 25 kg/m2 and 45 kg/m2 with the ability to fit the ambulatory blood pressure monitoring (ABPM) cuff per the manufacturer; * Subject must have a successful ABPM measurement prior to receiving the study drug. * Women of childbearing potential and non-surgically sterile male subjects who are sexually active must agree to use an approved highly effective form of contraception from the time of informed consent until 30 days post-dose. * Women of childbearing potential must have a negative serum pregnancy test result at Screening and a negative urine pregnancy test result at the Inclusion Visit (Day 0). Exclusion Criteria: * Known or suspected secondary HTN (eg, renal artery stenosis, pheochromocytoma, Cushing's disease); * Office SBP greater than or equal to 171 mmHg and/or office diastolic blood pressure (DBP) greater than or equal to 105 mmHg at the Inclusion Visit (Day 0) and confirmed by a second measurement (not on the same day), preferably within 1 day; * Known hypertensive retinopathy (Keith-Wagener Grade 3 or Grade 4) and/or hypertensive encephalopathy; * History of spontaneous or drug-induced angioedema; * Clinically significant valvular heart disease or severe aortic stenosis; * Subjects with symptomatic heart failure (New York Heart Association Class II to Class IV); * History of acute coronary syndrome (non-ST elevation myocardial infarction, ST elevation myocardial infarction, and unstable angina pectoris), stroke, or transient ischemic attack within 6 months prior to Screening; * Known history of malabsorption syndrome, or has undergone gastrointestinal surgery, including bariatric procedures, that induce chronic malabsorption, within 2 years of Screening; * Treatment with anti-obesity drugs or procedures 3 months prior to Screening (ie, surgery, aggressive diet regimen, etc.), leading to unstable body weight; * Female who is breast feeding, pregnant, or planning to become pregnant during the study period; * Medical history of cancer (except for basal cell carcinoma) and/or treatment for cancer within the last 5 years; * Subject with an upper arm circumference that exceeds the upper circumference level (48.3 cm) of the cuff size of either the ABPM and/or office BP (OBP) measurement device used in the study; * Night shift workers who routinely sleep during the daytime and/or whose work hours include midnight; * Alanine aminotransferase, aspartate aminotransferase, or alkaline phosphatase \>3 x upper limit of normal (ULN) or a total bilirubin greater than or equal to 2 x ULN (unless secondary to Gilbert's syndrome) at Screening or the Inclusion Visit (Day 0); * Estimated glomerular filtration rate \<45mL/min/1.73m2, as calculated using the Chronic Kidney Disease Epidemiology Collaboration formula at Screening or the Inclusion Visit (Day 0); * History of any blood disorder, other than sickle cell trait, causing hemolysis or unstable red blood cells (eg, malaria, babesiosis, hemolytic anemia, thalassemia, sickle cell anemia); * Subjects with type 1 diabetes mellitus; * Subjects with type 2 diabetes mellitus who: * Are poorly controlled, defined as hemoglobin A1c \>8% at Screening; or * Are taking short-acting insulin or sodium-glucose co transporter 2 inhibitors. Use of a stable dose (greater than or equal to 12 weeks prior to Screening) of medications listed in Appendix C is permitted; * Routine or anticipated treatment with all systemic corticosteroids. Use of topical, inhaled, or nasal corticosteroids is permitted; * Clinical evidence of thyroid disease, thyroid hormone therapy that is not stable greater than or equal to 4 weeks prior to Screening, or subjects with the following thyroid-stimulating hormone (TSH) levels at Screening: * For subjects on replacement therapy: TSH 0.75 to 1.5 x ULN; or * For subjects not on replacement therapy: TSH \>1.5 x ULN; * History of alcohol or drug abuse within the 3 months prior to Screening that would interfere with study participation or lead to decreased compliance to study procedures or study drug intake in the Investigator's opinion; * Participation in another clinical study involving an investigational drug within 30 days prior to Screening, or plans to participate in another clinical study within 30 days of discontinuation of study drug; * Any condition, in the opinion of the Investigator, that would interfere with study participation, may pose a risk to the subject, or would make study participation not in the best interest of the subject; * Subjects with a life expectancy of less than 1 year per Investigator's discretion; or * Any subject who, in the opinion of the Investigator, will not be able to follow the protocol.