Catestatin and Hypertension in Pregnancy

Inclusion Criteria: * Healthy pregnancy women * Pregnancy women with hypertension 1. Despite the pregnant gestational age , systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured three times more than 24 hours apart 2. Pregnant gestational age \> 20 weeks, systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured twice more than 4 hours apart Exclusion Criteria: * Lack of blood sample at the specified enrollment period * Women who refuse the study * Other illness which needs medications interfering with blood pressure (eg: Asthma requiring systemic steroids) * Known coronary artery disease or heart failure * Serious medical illness (eg: renal insufficiency, congestive heart disease, chronic respiratory insufficiency, uncontrolled infection). * multiple endocrine neoplasia or Cushing's syndrome or mixed tumours or pheochromocytoma or medullary thyroid carcinoma. * previous history of malignant tumour, with the exception of carcinoma in situ of the uterine cervix or non-melanoma skin cancer * renal insufficiency