This diagnostic test is aimed to compare the Karyotyping, CMA and NIPT for prenatal diagnosing chromosomal anomalies. Pregnant women who needed prenatal genetic diagnosis meted the study criterion; fetal amniotic fluid was regular examined by Karyotyping and CMA, and maternal peripheral blood was collected for NIPT detecting. And the CMA result as a golden standard, the main outcome is compared the diagnostic efficacy of NIPT for diagnosing chromosomal anomalies.
Aim: to compare the Karyotyping, CMA and NIPT for prenatal diagnosing chromosomal anomalies. Design: diagnostic test Set: Prenatal diagnosis center of Taizhou City Study population: The Pregnant women who needed amniocenteses for prenatal genetic diagnosis were recruited. Methods: amniotic fluid was regular examined by Karyotyping and CMA, and maternal peripheral blood was used for collected for NIPT detecting. Statistic: CMA result as a golden standard, the main outcome is compared the diagnostic efficacy of NIPT for diagnosing chromosomal anomalies.
Study Type
OBSERVATIONAL
Enrollment
1,000
Taizhou Hospital of Zhejiang province
Taizhou, Zhejiang, China
RECRUITINGaccuracy of NIPT for prenatal diagnosing chromosomal anomalies
sensitive, false negative rate, and false positive rate of NIPT compared with CMA
Time frame: July,2016-July, 2017
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.