Immediate Versus Delayed FET Following a Stimulated IVF Cycle

N/ACompletedNCT03201783

ShangHai Ji Ai Genetics & IVF Institute724 enrolled

Overview

Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

724

Conditions

Fertilization in Vitro Embryo Transfer

Interventions

immediate frozen-thawed embryo transferOTHER

Frozen-thawed embryo transfer will be performed in the first cycle following the stimulated IVF cycle

delayed frozen-thawed embryo transferOTHER

Frozen-thawed embryo transfer will be performed at least in the second cycle following the stimulated IVF cycle

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 43 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women aged ≤43 years at the time of IVF/ICSI treatment Undergoing IVF with a standard stimulation At least one frozen embryo or blastocyst The first FET cycle following ovarian stimulation in IVF/ICSI Exclusion Criteria: * Use of mild stimulation or natural cycle for IVF/ICSI treatment Severe ovarian hyperstimulation syndrome during IVF/ICSI treatment Preimplantation genetic diagnosis treatment Use of donor oocytes Presence of hydrosalpinx which is not surgically treated or endometrial polyp on scanning during ovarian stimulation

Locations (1)

ShangHai JIAI Genetics&IVF Institute

Shanghai, China

Outcomes

Primary Outcomes

ongoing pregnancy

viable pregnancy beyond gestation 12 weeks

Time frame: viable pregnancy beyond gestation 12 weeks

Secondary Outcomes

Positive hCG level

the result of serum β-hCG ≥10 mIU/mL.

Time frame: A blood pregnancy test is performed 14 days after the FET

clinical pregnancy

presence of intrauterine gestational sac on ultrasound

Time frame: presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy

biochemical pregnancy:

positive blood pregnancy test not followed by clinical pregnancy

Time frame: positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation

implantation rate

number of gestational sacs per embryo transferred

Time frame: number of gestational sacs per embryo transferred during 4 weeks of pregnancy

multiple pregnancy

more than one intrauterine sacs on scanning

Time frame: multiple pregnancy beyond gestation 12 weeks

ectopic pregnancy

pregnancy outside the uterine cavity

Time frame: ectopic pregnancy during 12 weeks gestation

miscarriage

the loss of a pregnancy before 22 weeks gestation

Time frame: the loss of a pregnancy before 22 weeks gestation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.