The purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.
The reinforcing value of food varies greatly among individuals, but is strongest for those who are overweight or obese. Reducing energy intake, which is necessary for overweight and obese individuals to achieve a healthier body weight, increases the reinforcing value of food - especially for energy-dense snack foods. Food is a powerful reinforcer and is associated with energy intake; making it a primary contributing factor to an individual's weight loss struggle. Developing a way to decrease or limit the increase in food reinforcement during energy deficits would have important clinical impact. High-protein diets are known to be efficacious for weight loss and recently have been shown to decrease stimulation of the reward areas of the brain that stimulate reward-driven eating behavior. Nonetheless, sustaining a high-protein diet can be difficult, especially for women. Consuming a modest amount of protein at each meal may be better tolerated. However, we do not know whether this pattern of protein intake can assist women in staying "on track" with weight loss goals. This study will help begin to elucidate the connections between the daily pattern of protein intake on diet adherence, alterations in food reinforcement, and favorable body composition changes during weight loss.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
45
Intake of even protein 5 day rotating menu
Intake of skewed protein 5 day rotating menu
USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States
Body Composition
Determine the effects of two patterns of daily protein intake on changes in fat mass and fat-free mass during weight loss.
Time frame: 8 and 16 weeks
Diet Adherence
Determine the effects of two patterns of daily protein intake on weight loss diet adherence and putative mediators (satisfaction, satiety, hunger, and reinforcing value of energy dense foods) of adherence.
Time frame: 16 weeks
Barriers to weight control
Nominal Group Technique results providing an exhaustive list of barriers to weight control in overweight and obese women
Time frame: 1 hour
Change in skeletal muscle protein breakdown
The effect of consuming two patterns of daily protein intake on 3-Methylhistidine degradation, a biochemcial marker of skeletal muscle protein breakdown
Time frame: 8 and 16 weeks
Circulating carotenoid levels
The effect of consuming two patterns of protein intake during weight loss on circulating carotenoid levels.
Time frame: 8 and 16 weeks
Relative reinforcing value (RRV) of food
The effect of consuming two patterns of daily protein intake during weight loss on the RRV of energy-dense snack food
Time frame: 8 and 16 weeks
Change in bone turnover
The effect of consuming two patterns of daily protein intake during weight loss on osteocalcin, alkaline phosphatase, acid phosphatase, and collagen cross-link molecules -- biochemical markers of bone formation and resorption
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Time frame: 8 and 16 weeks
Plasma lipids
The effect of consuming two patterns of daily protein intake during weight loss on lipid and triglyceride molecular speciation.
Time frame: 8 and 16 weeks