Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

N/ACompletedNCT03202823

Centre Hospitalier Universitaire Dijon204 enrolled

Overview

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Study Type

OBSERVATIONAL

Enrollment

204

Conditions

Carotid Stenosis

Interventions

blood samplesPROCEDURE

3 tubes (5 ml volume) collected during surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who have provided explicit consent * Patients older than 18 years * Patients about to undergo surgery for carotid stenosis * Haemoglobin ≥ 7g/dl at the time the sample is taken * Respect the maximum volume of blood taken (treatment + research) in 30 days SPECIFIC TO DIABETICS \- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier Exclusion Criteria: * Patients under guardianship * Patients without health insurance cover * Pregnant or breast-feeding women

Outcomes

Primary Outcomes

Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects

Time frame: Baseline