Comparison of Volume Controlled Ventilation With 1:1 Inspiratory to Expiratory Ratio and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

N/ACompletedNCT03202953

Yonsei University78 enrolled

Overview

The purpose of this study is to compare the 1: 1 I: E ratio VCV and the autoflow VCV in patients undergoing robot assisted laparoscopic prostatectomy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Robot Assisted Laparoscopic Prostatectomy

Interventions

ventilation strategy 1PROCEDURE

In Group I, after trendelenburg position, patients will be applied 1:1 ratio VCV. * Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:1, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.

ventilation strategy 2PROCEDURE

In group A, after trendelenburg position, patients will be applied autoflow VCV. \- Tidal volume : 8ml/kg, inspiration:expiration ratio = 1:2, FiO2 = 0.5, maintain end tidal CO2 around 40±5 mmHg. Positive end expiratory pressure will not used.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. adult (20-80 years old) 2. patients undergoing robot assisted laparoscopic prostatectomy Exclusion Criteria: 1. history of COPD 2. decreased heart function (EF \<50%) 3. BMI\>30 4. patients who cannot read the consent form (e.g., blind, foreigner)

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

PaO2

PaO2 analyzed by arterial blood gas analysis

Time frame: 30 minutes after trendelenburg position