Myocellular Signalling in Skeletal Muscle

N/ACompletedNCT03203317

University of Copenhagen8 enrolled

Overview

The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Exercise Insulin Sensitivity

Interventions

InsulinDRUG

2 h insulin clamp

ExerciseOTHER

Cycling exercise

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy * informed consent * habitual training (2-5 h/week) * VO2max of 40-60 ml/min/kg * lean mass 55-65 kg Exclusion Criteria: * smoker * allergy towards insulin * chronic disease

Locations (1)

August Krogh Building

Copenahgen, Denmark

Outcomes

Primary Outcomes

Change in muscle phospho-proteome signature

proteomic analysis of mixed muscle homogenate

Time frame: Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation

Data from ClinicalTrials.gov

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