Corneal Nerve Structure in Sjogren's

N/ACompletedNCT03203382

University of Pennsylvania100 enrolled

Overview

Patients who are suspected of or diagnosed with Sjogren's disease will be evaluated for ocular symptoms and corneal nerve morphology. We are specifically interested in the relationship between Vitamin D level and aberrations in the morphology of the corneal nerves.

Patients with either suspected or confirmed diagnosis of Sjogren's disease will be recruited to participate. Participation will involve the completion of a brief survey (the OSDI), corneal evaluation with an aesthesiometer, corneal staining with fluorescein and lissamine green, and finally measurement of tear-film breakup time. In addition, participants will have their corneal nerve morphology evaluated with the Heidelberg confocal microscope and finally they will have a blood draw performed to assess vitamin D level.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sjogren's Syndrome Vitamin D Deficiency

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Suspected or confirmed Sjogren's syndrome * 18+ years of age Exclusion Criteria: * Any condition that in the opinion of the investigator may confound study results or cause concerns for safety

Locations (1)

Scheie Eye Institute of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Corneal Nerve Morphology

Heidelberg Retina Tomograph with the Rostock Cornea Module

Time frame: one time exam

Vitamin D Level

serum

Time frame: one time exam at baseline, day 1

Secondary Outcomes

vital dye staining

corneal staining

Time frame: one time exam at baseline, day 1

Data from ClinicalTrials.gov

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