This is a prospective, multi-center, observational study, the primary objective is to evaluate the prevalence of gBRCA/sBRCAm in newly diagnosed ovarian cancer patients and explore ovarian cancer treatment outcomes of different BRCAm status
This is a prospective, multi-center, observational study that will enroll consecutive patients with a confirmed diagnosis of epithelial ovarian cancer, fallopian tube, or peritoneal cancer and who consent to a blood draw, a tissue sample analysis, and follow up for collection of data. 900 newly diagnosed ovarian cancer patients will be enrolled and evaluated for Breast Cancer Susceptibility genes BRCA1 and BRCA2 germline and somatic mutations (BRCAm). Approximately 170 BRCAm positive patients and 170 negative patients will be followed in the Follow-up Period. This study aims to answer very important questions regarding the prevalence of gBRCAm and sBRCAm in a population of newly diagnosed ovarian cancer patients, and the relationship of these mutations to patient treatment and clinical outcomes. These answers may be extremely helpful in the counseling and treatment of genetic risk in these populations and may aid in making treatment decisions in the future.
Study Type
OBSERVATIONAL
Enrollment
29
Research Site
Hefei, Anhui, China
Research Site
Beijing, Beijing Municipality, China
Proportion of newly diagnosed ovarian cancer patients with gBRCA and sBRCA mutations
To evaluate the prevalence of gBRCA mutation and sBRCA mutation in newly diagnosed ovarian cancer patients
Time frame: 1 year
Progression-free survival (PFS)
To describe ovarian cancer treatment outcomes in patients during the Follow up Period in terms of PFS
Time frame: 18 months
Overall survival (OS)
To describe ovarian cancer treatment outcomes in patients during the Follow up Period in terms of OS
Time frame: up to 5 years
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Research Site
Beijing, Beijing Municipality, China
Research Site
Beijing, Beijing Municipality, China
Research Site
Chongqing, Chongqing Municipality, China
Research Site
Guangzhou, Guangdong, China
Research Site
Guangzhou, Guangdong, China
Research Site
Guangzhou, Guangdong, China
Research Site
Zhengzhou, Henan, China
Research Site
Wuhan, Hubei, China
...and 9 more locations