Trace Element Repletion Following Severe Burn Injury

N/ACompletedNCT03204669

Centre Hospitalier Universitaire Vaudois139 enrolled

Overview

Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome. The study aimed to check if our repletion protocols were achieving normalization of TE plasma concentrations of major burn patients and if the necessity for continuous renal replacement therapy (CRRT) might increase the needs.

Retrospective analysis of prospectively collected data in burn patients requiring intensive care (ICU) between 1999 and 2015. The cohort was divided into 4 groups according to the protocol changes. Period 1 (P1): 1999-2000, P2: 2001-2005, P3: 2006-2010, P4: 2011-2015. Changes consisted mainly in increasing TE repletion doses and duration. Demographic data, daily TE intakes and weekly plasma concentrations were retrieved for the first 21 ICU-days.

Study Type

OBSERVATIONAL

Enrollment

139

Conditions

Critical Illness Nutritional Deficiency Trace Element Deficiency Burn Injury

Interventions

Trace elements replacementOTHER

Eligibility

Sex: ALLMin age: 14 YearsMax age: 86 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Burn injury involving ≥20% body surface (TBSA) (i.e. the threshold for intravenous TE repletion prescription) * At least one TE plasma concentration during the ICU stay Exclusion Criteria: * Comfort care * Admission \>24h after burn injury

Locations (1)

Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois)

Lausanne, Switzerland

Outcomes

Primary Outcomes

Trace elements plasma concentration

Copper, Selenium and Zinc plasma concentrations, measured by inductively coupled plasma mass spectrometry (ICP-MS). The recommendation was to check them on a weekly basis.

Time frame: 21 days

Secondary Outcomes

Number of infectious complications

Infectious complications retrieved from the discharge reports, based on microbiological findings and antibiotherapy introduction or rotation. Multiple positive cultures were considered only once when they were related to a unique infectious episode. Concomitant sites of infection, including primary bloodstream infections, were considered as separate episodes of infections. Episodes of infections due to several microorganisms were considered only once. Infections were defined according to the criteria of the Center for Disease Control (CDC), American Burn Association (ABA) and International sepsis forum.

Time frame: 21 days

Length of mechanical ventilation

Number of days on the ventilator by the time the patient is discharged from hospital.

Time frame: Up to 120 days

Length of stay

Number of days spent in the ICU by the time the patient is discharged from hospital.

Time frame: Up to 250 days

Data from ClinicalTrials.gov

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