Endometriosis is associated with different types of pain (acute, chronic, excess nociception, neuropathic) generated by different mechanisms in the nervous system. The rTMS could provide significant analgesia for refractory endometriosis pain. The aim of the study is to evaluate the feasibility of transcranial magnetic stimulation (rTMS) for analgesia on chronic refractory endometriosis pain.
The first step consists of the inclusion of 12 patients followed by the filling by each patient of the RedCap software of five simple numerical scales for 4 weeks . Realization of a brain and medullary MRI to allow neuronavigation. Realization of 5 sessions of rTMS in 5 days during the first week then evaluation (physical examination, questionnaires) in consultation on post-stimulation. Then followed for 28 days in total through self-assessment of pain that will be filled daily on REDCap and last consultation on D28 for further evaluation
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Realization of a brain and medullary MRI to allow neuronavigation. Realization of 5 sessions of rTMS in 5 days during the first week then evaluation (physical examination, questionnaires) in consultation on post-stimulation. Then followed for 28 days in total through self-assessment of pain that will be filled daily on REDCap and last consultation on D28 for further evaluation
CHU de Clermont-Ferrand
Clermont-Ferrand, Auvergne, France
RECRUITINGPercentage of patients tolerant 5 sessions of stimulation and with no increase in pain
The feasibility of rTMS treatment was defined if 7 patients or more over 12 tolerate the 5 sessions of stimulation showed no increase in pain
Time frame: at day 8
Change in pain between the mean pain evaluated before inclusion
thanks to the visual analogue scale traded between 0 and 100
Time frame: at day 8
Endometriosis Health Profile Questionnaire (EPH-30);
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
Brief Pain Inventory (BPI): digital
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
Beck Questionnaire (Depression)
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
STAI of Anxiety Scale; Scale of alexythymie of Toronto
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
Catastrophizing Pain Scale (personality)
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
Quality of Life Questionnaire SF-36
Variation in scores of questionnaires before and after stimulation
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Time frame: at day 8
Migraine criteria (ICHD3)
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8
Gastrointestinal quality of Life Index (GICLI)
Variation in scores of questionnaires before and after stimulation
Time frame: at day 8