A Prospective, open, randomized, controlled clinical study to evaluate the efficacy and safety of PEG-rhG-CSF(PEGylated recombinant human granulocyte stimulating factor injection) in reducing neutropenia during TP(docetaxel+cisplatin) regiment simultaneous radiochemotherapy and adjuvant chemotherapy in patients with cervical cancer
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
PEG-rhG-CSF single-dose was administered subcutaneously 48h after chemotherapy,weight ≥ 45kg were given 6mg once per chemotherapy cycle, weight \<45kg were given 3mg once per chemotherapy cycle.
rhG-CSF was administered subcutaneously 48h after chemotherapy,weight≥45kg were given 300μg/d, weight\<45kg were given 150μg/d,continuous injection for 3-5 days until the absolute neutrophils count≥2×10\^9/L.
Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China
Incidence of III/IV neutropenia
The incidence of III/IV neutropenia in each chemotherapy cycle
Time frame: 3 months
Incidence of FN
Incidence of febrile neutropenia (FN) in each chemotherapy cycle
Time frame: 3 months
Proportion of chemotherapy dose adjustment
Proportion of chemotherapy dose adjustment due to neutropenia
Time frame: 3 months
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