This study will investigate the effect of Repetitive transcranial magnetic stimulation (rTMS) on cognition and long-term clinical outcomes of bipolar patients.
Cognitive deficits are core features of bipolar disorder. Preliminary evidence shows that repetitive transcranial magnetic stimulation (rTMS) might have positive effects in enhancing cognition and improving clinical symptoms in patients with depression. This study will investigate the effect of rTMS on cognition and long-term outcomes (12 month) of bipolar patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
42
Daily left DLPFC, at 110% motor threshold, with a frequency of 10 Hz. Stimulation will be applied in 3-second trains with a 15-second inter-train interval, for 50 trains per session
Sham Transcranial Magnetic Stimulation
Guangzhou Brain hospital(Guangzhou Huiai Hospital)
Guangzhou, Guangdong, China
Changes in the MATRICS Consensus Cognitive Battery
Changes in neurocognitive and social function (measured by the The MATRICS Consensus Cognitive Battery) after 2 session of rTMS treatments (20 times)
Time frame: one weeks after the completion of the rTMS treatment)
relapses of depressive and/or hypo/mania episode
The number of patients who have depression and/or hyop/mania episodes over period of 12 months.
Time frame: 12 months
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