Inhaled Nitric Oxide for Patients With MABSC

Inclusion Criteria: 1. Subjects (Male or female) between 6 to 65 years old 2. Diagnosis of pulmonary non-tuberculosis mycobacterial lung disease in accordance with the 2007 ATS/IDSA criteria with evidence of nodular bronchiectasis and/or cavitary disease by chest computed tomography (CT) and by culture. 3. History of at least 6 months chronic infection with Mycobacterium abscessus. 4. Mycobacterium abscessus positive sputum sample at screening or prior to screening. 5. Receiving ATS/IDSA guidelines-based treatment regimen defined as: adherent to a multi-drug regimen for at least 6 months prior to screening with persistently positive mycobacterial abscessus cultures. 6. FEV1 ≥ 30% at screening as well as baseline. 7. Ability to produce sputum or be willing to undergo an induction of sputum for clinical evaluation. 8. Life expectancy ≥1 year 9. Ability to perform 6MWT, but not to exceed a distance of 700 meters during screening. 10. Ability to understand and comply with study requirements. 11. Approved and signed informed consent by subject and/or by parent/legal guardian (depending on subject's age). Exclusion Criteria: 1. Breastfeeding or pregnancy as evidenced by a positive pregnancy test. 2. Subjects diagnosed with methemoglobinemia, immunodeficiency, heart disease, pulmonary hypertension and/or high blood pressure. 3. Use of an investigational drug during the last 30 days prior enrollment and/or the subject is expected to participate in a new study within five months from enrollment to this study. 4. History of frequent epistaxis (\>1 episode/month). 5. Significant hemoptysis during the last 30 days prior to enrolment (\>30 Ml of blood in a 24-hour period). 6. Methemoglobin level \>2% at screening. 7. Patients on inconsistant dosage of systemic steroids (any formulation) 30 days prior to enrolment. 8. History of illicit drug or medication abuse within 1 year of screening. 9. History of lung transplantation. 10. History of daily, continuous oxygen supplementation. 11. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the subject or the quality of the data. 12. Pulmonary tuberculosis requiring treatment or treated within 2 years prior to screening. 13. Any change in chronic NTM multi-drug regimen within 28 days prior to study day 1.