Vascular Effects of a Single Bout of Electronic Cigarette Use

Phase 1CompletedNCT03209661

University of Texas at Austin16 enrolled

Overview

Investigating the acute effects of a single use E-Cigarette upon vascular health.

Subjects will inhale e-cigarettes of 5.4%, 0%, and sham menthol inhaler to determine the effects upon to measures of vascular health. These measures will include Cardio-Ankle Vascular Index and Flow Mediated Dilation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Arterial Stiffness

Interventions

E-cigaretteDRUG

E-Cigarette containing 5.4% nicotine will be administered to determine the effects on vascular function.

Nicotine 0%DRUG

E-Cigarette containing 0% nicotine will be administered to determine the effects on vascular function.

Menthol Inhalant ProductDRUG

Menthol inhaler will be administered to determine the effects on vascular function.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Apparently healthy, with no cardiovascular or metabolic diseases. Additionally, is not a frequent smoker of any kind. Exclusion Criteria: * Cardiovascular or Metabolic Diseases and/or regular smoker.

Locations (1)

Cardiovascular Aging Research Lab at UT Austin

Austin, Texas, United States

Outcomes

Primary Outcomes

Changes in arterial stiffness and endothelial function with e-cigarette use.

Arterial stiffness and endothelial function are two of the subclinical markers of vascular dysfunction

Time frame: Immediately Post, 1 hour, and 2 hour.

Data from ClinicalTrials.gov

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