Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint

University Hospital, Grenoble10 enrolled

Overview

Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.

Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Knee Osteoarthritis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years of age * Knee prosthetic surgery indication with cartilage excision. Exclusion Criteria: * Subjects who refuse to sign a non-objection form

Locations (1)

Orthopedic Surgery Department, University Grenoble Hospital

Grenoble, France

Outcomes

Primary Outcomes

Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint.

Correlation between Osteoarthritis Research Society International (OARSI) grades performed for different modalities

Time frame: 6 months

Secondary Outcomes

Evaluation of 9,4 Tesla MRI reconstructions in early osteoarthritis evaluation using visual qualitative information parameter obtained from the Average Pathlength Maps (APM).

Correlation between MRI quantitative parameters and gold standard OARSI grade

Time frame: 6 months

Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual qualitative information parameter.

Correlation between quantitative parameters from FFOCT and gold standard OARSI grade

Time frame: 6 months

Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual qualitative information parameter.

Correlation between quantitative parameters from navigation ultrasound and gold standard OARSI grade

Time frame: 6 months

Evaluation of of 9,4 Tesla MRI reconstruction in early osteoarthritis evaluation using visual quantitative information parameter obtained for the Average Pathlength Maps.

Correlation between quantitative parameters from the Average Pathlength Maps and gold standard OARSI grade

Time frame: 6 months

Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter.

Thickness average of cartilage

Time frame: 6 months

Data from ClinicalTrials.gov

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