Comparison of Duration of Treatment Interruption With or Without Curcumin During the Off Treatment Periods in Patients With Prostate Cancer Undergoing Intermittent Androgen Deprivation Therapy

Inclusion Criteria: * patients diagnosed with prostate cancer in biopsy * among patients with biochemical recurrence after treatment(radical prostatectomy, radiation therapy, focal therapy, etc.) for localized prostate cancer or metastatic prostate cancer at the time of diagnosis, who received intermittent androgen deprivation therapy(IAD) * patients who off-treatment for the first time by receiving androgen deprivation therapy(ADT) for more than 6 months and PSA nadir remained stable for more than 3 months Exclusion Criteria: * previous history of IAD * patient with other serious or ongoing medical or psychiatric disease other than prostate cancer * hypersensitivity or suspicious of curcumin * history of taking health supplements containing curcumin for prostate cancer treatment before 6 months of clinical trial participation