Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone

Hillel Yaffe Medical Center115 enrolled

Overview

The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

115

Conditions

Obstetric Labor, Premature

Interventions

Culture with progesteroneBIOLOGICAL

Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells

Culture without progesteroneBIOLOGICAL

Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone

Culture with growth factorsBIOLOGICAL

Culture of placental IMC cells with growth hormones only and analysis

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Placentas from term and preterm deliveries * Singleton pregnancy * Consent to participate Exclusion Criteria: * Pregnancies with obstetric complications * Multiple gestation * Maternal illness or fetal malformation known pre-delivery

Locations (1)

Hillel Yaffe Medical Center

Hadera, Israel

Outcomes

Primary Outcomes

Inflammation characteristic effects of progesterone on preterm and term placentas

Differences observed in cytokine profiles of IMC cells from term and preterm placentas cultured with and without progesterone

Time frame: One year

Maturation effects of progesterone on preterm and term placentas

Differences observed in maturation of IMC cells into DC cells in term and preterm placentas

Time frame: One year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.