A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.
Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.
Study Type
OBSERVATIONAL
Enrollment
960
Occupational history
To include analysis of known susceptibility markers
Imperial Healthcare NHS Trust
London, United Kingdom
Association between asbestos exposure and IPF
estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status
Time frame: 2 years
Dose-response relationship between asbestos exposure and IPF
estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status
Time frame: 2 years
Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.
MUC5B rs35705950 and asbestos exposure odds ratio.
Time frame: 2 years
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