The investigators hypothesize that perioperative oral administration of pregabalin would reduce postoperative pain and produce reduction in postoperative opioid consumption after anterior cruciate ligament (ACL) reconstruction . Patients are randomly assign to 1 of 2 groups. The placebo group receive placebo capsules 1 hour before surgery and 12 hours after initial dose. The pregabalin group receive pregabalin 150 mg, respectively at the same points.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
96
The intervention group receive pregabalin 150 mg 1 hour before surgery and 12 hours after initial dose.
The placebo group receive placebo 150 mg 1 hour before surgery and 12 hours after initial dose.
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine
Seoul, South Korea
Postoperative pain scores
Visual analog scale (VAS) score = 0-100 mm
Time frame: 12 hours after surgery
Postoperative pain scores
Visual analog scale (VAS) score = 0-100 mm
Time frame: 24 hours after surgery
Postoperative pain scores
Visual analog scale (VAS) score = 0-100 mm
Time frame: 36 hours after surgery
Postoperative pain scores
Visual analog scale (VAS) score = 0-100 mm
Time frame: 2 weeks after surgery
Opioid consumption
Time frame: the first 48 hours after surgery
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