This trial is conducted in Europe. The aim of this trial is to investigate the effect of abnormal liver (hepatic) function on the amount of trial drug getting into the body and removal of the drug from the body (this is called pharmacokinetics). In this trial the participants will receive three subcutaneous (under the skin) injections of the trial drug somapacitan. Somapacitan is a long-acting growth hormone analogue (a drug similar to human growth hormone) intended for once-weekly subcutaneous administration.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
34
3 once-weekly subcutaneous administrations (s.c., under the skin) of somapacitan with a dose of 0.08 mg/kg
Novo Nordisk Investigational Site
Bratislava, Slovakia
Area under the somapacitan serum concentration time curve
Calculated based on somapacitan measured in blood
Time frame: From time 0 to 168 hours after the last dosing on Day 15
Maximum serum concentration of somapacitan
Calculated based on plasma somapacitan activity measured in blood
Time frame: After the last dosing on Day 15 until Day 43
Time to maximum serum concentration of somapacitan
Calculated based on plasma somapacitan activity measured in blood
Time frame: After the last dosing on Day 15 until Day 43
Incidence of adverse events
Count
Time frame: From first dosing to Day 43
Occurrence of anti-somapacitan antibodies
Count
Time frame: From Day 0 to Day 43
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