Hypofractionated Radiation Therapy for Glioblastoma

Inclusion Criteria: * Patients 18 to 70 years of age with newly diagnosed and histologically confirmed glioblastoma. * WHO performance status of 2 or less and adequate hematologic, renal, and hepatic function. Exclusion Criteria: * Prior diagnosis of cancer, unless disease free for \> 3 years * Previous history of radiotherapy in the head and neck region (except initial larynx tumor - T1, T2 / N0M0). * Specific severe, active co-morbidities * Tumor located in the brainstem * Presence of leptomeningeal carcinomatosis * Multicentric tumor