Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding

Overview

Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding

A prospective cross sectional study on 150 consecutive patients screening for esophageal varices. Patient groups groups: Group (1): 100 patients with esophageal varices Group (2): 50 chronic liver disease patients with no esophageal varices as a control group. All patients will be subjected to: 1. \- Detailed history-taking 2. \- Full clinical examination 3. \- Laboratory investigations: * Complete blood picture (CBC) * Erythrocyte sedimentation rate (ESR) * Renal function tests * Liver function tests * Prothrombin time and activity * Viral markers (HCV Ab - HBV Ag) * Blood ammonia level. 4. \- Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen, kidney and other abdominal organs. 5. \- Upper GITendoscopy: * Varices will be classified according to the Japanese classification 1996, * The Baveno 11 score will be used to differentiate between mild and severe portal hypertensive gastropathy.

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Central Contacts