Ixazomib for Desensitization

Inclusion Criteria: * Male or female patients 18-70 years of age. * Able to provide informed consent. * Female patients who are postmenopausal for at least 1 year before the screening visit, or are surgically sterile, or If they are of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent form through 30 days after the last dose of study drug, OR agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence \[eg, calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception.) * Male patients, even if surgically sterilized (ie, status post-vasectomy), must agree to one of the following: Agree to practice effective barrier contraception during the entire study treatment period and through 30 days after the last dose of study drug, or Agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. (Periodic abstinence (eg, calendar, ovulation, symptothermal, post-ovulation methods\] and withdrawal are not acceptable methods of contraception.) * Patients must be highly sensitized with a cPRA ≥ 80% * Be active on the waitlist for kidney transplantation \> 24 months to confirm their inability to receive a deceased donor transplant because of their sensitization status. * Patients must meet the following clinical laboratory criteria: 1. Absolute neutrophil count (ANC) ≥ 1,000/mm3 and platelet count ≥ 75,000/mm3. Platelet transfusions to help patients meet eligibility criteria are not allowed within 3 days before study enrollment. 2. Hemoglobin higher than 6 g/dL 3. Total bilirubin ≤ 1.5 x the upper limit of the normal range (ULN). 4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN. Exclusion Criteria: * Female patients who are lactating or have a positive serum pregnancy test during the screening period * Major surgery requiring hospitalization within 6 months before enrollment * Infection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment * Evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months * Systemic treatment, within 14 days before the first dose of ixazomib, with strong CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of St. John's wort * Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol * Inability to take oral medication * Diagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection * Grade 2 or greater peripheral neuropathy according to NCI Common Terminology Criteria for Adverse Events (CTCAE) * Participation in other interventional clinical trials, including those with other investigational agents not included in this trial, within 6 months of the start of this trial and throughout the duration of this trial * Patients that have previously been treated with ixazomib, or participated in a study with ixazomib whether treated with ixazomib or not * Active or treated infection for HIV, HCV or HBV * History of Liver cirrhosis, biopsy confirmed * Elevated transaminases (greater than 3 times the upper limit of normal) * Known hypersensitivity to ixazomib * Active substance abuse by self-report or medical record