Recurrent oral aphthous ulcer is the most common oral lesion in occurrence and one of cause is oxidative stress so investigators need to use antioxidant drugs like topical coenzyme Q10 gel to treat the lesion and more safe for the participants.
Double randomized clinical trial study using two parallel group suffer from oral aphthous ulcer one take antioxidant topical q10gel and other group take placebo carpabol gel two times per day for seven days measuring outcome at fourth and seventh day including pain; healing period and clinical parameters. Sample size of study include 26 in each group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
52
Q10 gel will give 2 times /day after breakfast and evening meal for 7 days.
placebo carbapol gel will give 2 times /day after breakfast and evening meal for 7 days.
visual analogue scale
pain
Time frame: 7 days
scoring system(0-3)
Erythema surround lesion
Time frame: 7 days
cross sectional area William periodontal probe/mm
Cross sectional area
Time frame: 7 days
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