SIBO & SIFO After Colectomy

Augusta University100 enrolled

Overview

After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (\> 1 year).

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Small Intestinal Bacterial Overgrowth Small Intestinal Fungal Overgrowth Colectomy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: patients who were referred to a specialist motility center over 4 year period with: * Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort * history of colectomy * patients with no history of colectomy * patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan. * patients with glucose breath test and/or duodenal aspirate Exclusion Criteria: * patients with upper gut or small bowel surgery * Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities * Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome

Outcomes

Primary Outcomes

Prevalence of SIBO/SIFO

Patients with unexplained GI symptoms following colectomy and to compare this with a control group of patients with similar symptoms but without previous colectomy.

Time frame: 4-5 years

Secondary Outcomes

Response to treatment with antibiotics and antifungals

Secondary aim was to assess the response to treatment with antibiotics and antifungals in colectomy patiens with SIBO/SIFO

Time frame: 4-5 years

Data from ClinicalTrials.gov

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