The purpose of this study is to investigate the effect of BPS804 on strength/quality of bone in patients with Type I, III or IV Osteogenesis imperfecta using a special type of CT scanner. Participants will be treated for 1 year.
This study was previously posted by Mereo Biopharma and was transferred to Ultragenyx in February 2021.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
IV administration of BPS804 in 5% Dextrose solution
Mereo Investigator Site
Albuquerque, New Mexico, United States
Mereo Investigator Site
Houston, Texas, United States
Change in radial Trabecular Volumetric Bone Mineral Density (mgHA/cm3)
High Resolution Peripheral Quantitative Computated Tomography
Time frame: 12 months
Change in radial bone strength on Finite Element Analysis (N)
High Resolution Peripheral Quantitative Computated Tomography
Time frame: 12 months
Change in tibial Trabecular Volumetric Bone Mineral Density (mgHA/cm3)
High Resolution Peripheral Quantitative Computated Tomography
Time frame: 12 months
Change in tibial bone strength on Finite Element Analysis (N)
High Resolution Peripheral Quantitative Computated Tomography
Time frame: 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.