Safety and Efficacy of AS101 1% Oral Solution in Patients With Neovascular Age-Related Macular Degeneration (AMD)

Inclusion Criteria: 1. Patient is diagnosed with CNV from AMD in one or both eyes and eligible for any anti-VEGF treatment in one or two study eyes. 2. Patient is 50 years of age or older. 3. Patient underwent at least 3 consecutive Intravitreal anti VEGF injections of the same kind , Ranibizumab (Lucentis) or Bevacizumab (Avastin) in the study eye and have sub retinal or intraretinal fluid at day 1, as found in OCT examination. 4. Patient must understand and sign the IRB-approved informed consent document for the study. 5. Patient must have BCVA of at least 20/200 in the study eye. 6. While unlikely, female patients of childbearing potential must not be pregnant or breast-feeding an must be willing to undergo serum pregnancy tests throughout the study. Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of child-bearing potential. 7. Both female patients of childbearing potential and male patients able to father a child must have (or have a partner who has) an acceptable method of contraception (such as hormonal or condoms) throughout the course of the study and for 4 weeks after the last study medication administration. 8. Patient must be willing and able to comply with the study procedures. Exclusion Criteria: 1. Patient exhibits evidence of retinal angiomatous proliferation in the study eye. 2. Patient has retinal-choroidal anastomosis in the study eye. 3. Patient has a history of treatment for CNV in the study eye with verteporfin, transpupillary thermotherapy, laser photocoagulation, external beam radiation therapy, or other local treatment (such as submacular surgery). 4. Patient has a history of systemic, periocular or intraocular steroid use at any time during the 12 weeks prior to enrollment. 5. Patient has a corneal melting, necrotizing keratitis/scleritis, scleritis of an infectious etiology or impending vision loss. 6. Patient has a known underlying systemic disease with evidence of a serious or potentially lethal uncontrolled active disease in one or more extraocular organ systems for which a defined effective medical regimen is indicated. 7. Patient has active pulmonary tuberculosis or active viral hepatitis. 8. Patient has a significant active infection. 9. Patient has significant renal or hepatic function impairment greater than mild (grade 2) as per CTCAE v4.0 or hypercholesterolemia uncontrolled by medication and/or diet. 10. Pregnant patients or lactating. 11. Patient has a history of malignancy within the past two years other than non-melanoma skin cancer. 12. Patient has an autoimmune systemic disease requiring immunosuppressive treatment or patient has other medical condition that renders the patient immunocompromised. 13. Patient received a live vaccine within past six weeks. 14. Patient has significant ocular or periocular inflammation or infection in either eye. 15. Patient has the presence of active or inactive toxoplasmosis in the study eye. 16. Patient is scheduled for surgery during study. \-