A retrospective hospital-based cohort study of the association between preoperative cardiopulmonary exercise test (CPEX) variables and short-term postoperative morbidity following oesophagectomy.
The aim of this study is to examine the correlations between preoperative CPEX variables (VO2max and Anaerobic Threshold) and 30 day postoperative all cause morbidity in a sample large enough to allow (should significant associations exist) calculation of a threshold value. Secondary aims are to examine associations between the VO2max, AT and cardiopulmonary, non-cardiopulmonary complications as well as specific complications (atrial fibrillation, pneumonia, and anastomotic leak) as well as 30 and 90 day mortality.
Study Type
OBSERVATIONAL
Enrollment
254
Aerobic fitness measured using a cycle ergometer and metabolic cart
Norfolk and Norwich University Hospital
Norwich, Norfolk, United Kingdom
All cause postoperative morbidity
Classified using Esophageal Complications Consensus Group (ECCG) definitions \[1\] and graded using Clavien-Dindo severity classification \[2\].
Time frame: 30 days
Cardiopulmonary complications
Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Time frame: 30 days
Non-cardiopulmonary complications
Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Time frame: 30 days
Mortality
All cause mortality.
Time frame: 30 days
Mortality
All cause mortality.
Time frame: 90 days
Pneumonia
Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Time frame: 30 days
Atrial fibrillation
Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Time frame: 30 days
Anastomotic leak
Classified using ECCG definitions and graded using Clavien-Dindo severity classification.
Time frame: 30 days
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