Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

University Hospital Hradec Kralove15 enrolled

Overview

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx. The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled. Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endothelial Dysfunction

Interventions

Sublingual microcirculation assessmentDEVICE

Non-invasive investigation of the endothelial glycocalyx in the sublingual microcirculation.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in ICU * indication for lipid administration as a part of TPN Exclusion Criteria: * shock or clinical/laboratory signs of tissue hypoperfusion * previous lipid infusions (within 3 months before entering study) * hyperlipidaemia * hyperglycaemia (over 10 mmol/l) * current or previous (within 72 hours before entering the study) use of propofol * pancreatitis * severe liver failure * current use of statins

Locations (1)

University Hospital Hradec Kralove

Hradec Králové, Třebeš, Czechia

Outcomes

Primary Outcomes

Endothelial Glycocalyx Thickness

Endothelial glycocalyx thickness was measured indirectly by PBR, which is a lateral movement of the red blood cells from the median column in the microcirculation in micrometers. The higher the PBR is the more damaged the endothelial glycocalyx is.

Time frame: One week within the ICU care

Data from ClinicalTrials.gov

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