The purpose of the study is to explore whether femtosecond laser-assisted cornea epithelial autograft is more effective than limbal conjunctival autograft for ocular surface reconstruction after excision of pterygium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
After removal of the recipient's pterygium tissue, a donor epithelial tissue equal in length to the bared limbus, will be obtained from the peripheral epithelial of the same eye (corneal epithelial autograft) using femtosecond laser technology. The epithelial graft will be sutured to the recipient limbal bed, with the goal of reconstruction of palisades of Vogt. The graft will act as a barrier to regrowth of pterygium. The area of the graft will be left with the Tenon capsule exposed.
After removal of the recipient's pterygium tissue, an adjustable diamond knife will be used to create a superficial circumferential incision at the corneal end of the limbal vascular arcade, equal in length to the bared limbus. This will be followed by harvesting the limbal-conjunctival flap. The limbal-conjunctival autograft will be sutured to the recipient bed, with the Tenon capsule exposed. The graft will serve as a barrier to regrowth of pterygium.
Zhongshan Ophthalmic Center, Sun Yat-sen Univerisity
Guangzhou, Guangdong, China
RECRUITINGRestoration of corneal surface
Restoration of a completely epithelized, stable, and avascular corneal surface
Time frame: 1 year
Recurrence of pterygium
To observe recurrence of pterygium using slit-lamp microscopy
Time frame: 1 year
Reconstruction of palisades of Vogt
To observe the reconstruction of palisades of Vogt using in vivo confocal microscopy.
Time frame: 1 year
Best corrected visual acuity
To assess changes of best corrected visual acuity using ETDRS chart
Time frame: 1 year
Corneal power and astigmatism
To assess changes of corneal power and astigmatism using autorefractor keratometer
Time frame: 1 year
Corneal haze measurement
To observe the scatter of corneal haze using in vivo confocal microscopy
Time frame: 1 year
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Simple removal of the recipient's pterygium tissue, with the Tenon capsule exposed.
A diamond knife to create a particular shaped limbal graft for transplantation
A commercial femtosecond laser to create a particular shaped graft for transplantation