The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach. A reduction in analgesic consumption and improvement in hemodynamics are expected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
198
Effector site concentration of remifentanil based on SPI
Effector site concentration of remifentanil based on hemodynamic data
Policlinico Duilio Casula
Monserrato, Cagliari, Italy
RECRUITINGRemifentanil consumption
Cumulative remifentanil consumption throughout surgery
Time frame: Intraoperative
Hemodynamics
Cumulative number of episodes of hypotension or hypertension or brady/tachycardia
Time frame: intraoperative
Desflurane
Cumulative consumption of desflurane (ml) as measured by datex ohmeda aysis ventilator
Time frame: intraoperative
Extubation delay
Timespan between end of surgery and extubation
Time frame: intraoperative
Post-operative analgesia 1
Evaluate the total consumption of analgesics in the first 24 hours after surgery
Time frame: 24 hr post operative
Post-operative analgesia 2
measure pain in the first post-operative day
Time frame: 24 hr post operative
Adverse reactions
Nausea and vomiting in the 1st post-operative day
Time frame: 24 hr post operative
Patient satisfaction
Evaluate on a 0-4 numeric scale patient satisfaction
Time frame: 24 hr post operative
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