The University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health \& Major Birth Defects Control and Prevention Project, which is funded by the Ministry of Science and Technology of China. The Project is led by Prof. Zhao Yangyu, from the Department of Gynecology \& Obstetrics, Peking University Third Hospital, and the UNIHOPE cohort is led by Prof. Jian-meng Liu, the Co-PI of the Project.
The UNIHOPE Cohort is set up to provide comprehensive evidence for the prevention and treatment of gestational complications in pregnant women with advanced maternal age, and therefore, to meet the growing clinical challenges of increasing pregnant women with advanced age in the two-child era. The UNIHOPE Cohort is planning to recruit 22,000 pregnant women aged ≥35 years from 9 large obstetrical center of major University-affiliated Hospitals across China, between July 2016 and December 2020. All women will be enrolled prior to 14 wks of gestation, followed up at 24-28 wks, 32-34 wks of gestation, delivery, and 42 days postpartum. Data including demographics, medical history, reproductive history, prenatal health care, gestational complications, and pregnancy and birth outcomes will be collected via electronic data capture system. Venous blood of the pregnant women will be collected at enrollment and each follow-up visit during pregnancy, and placental tissue, cord blood and hair of the newborn will also be collected.
Study Type
OBSERVATIONAL
Enrollment
22,000
Peking University First Hospital
Beijing, China
ACTIVE_NOT_RECRUITINGBeijing Obstetrics and Gynecology Hospital, Capital Medical University
Beijing, China
ACTIVE_NOT_RECRUITINGPeking University Third Hospital
Beijing, China
RECRUITINGWest China Second University Hospital
Chengdu, China
ACTIVE_NOT_RECRUITINGThe First Affiliated Hospital of Chongqing Medical University
Chongqing, China
RECRUITINGThe Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
ACTIVE_NOT_RECRUITINGObstetrics and Gynecology Hospital of Fudan University
Shanghai, China
ACTIVE_NOT_RECRUITINGShengjing Hospital of China Medical University
Shenyang, China
ACTIVE_NOT_RECRUITINGTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
ACTIVE_NOT_RECRUITINGIncidence of major gestational complications and adverse pregnancy outcomes in pregnant women with the advanced age, for a singleton or twin and higher order multiple gestation
Gestational diabetes mellitus, hypertensive disease of pregnancy, uterine scar pregnancy, placenta previa, preterm delivery, postpartum hemorrhage, low birth weight, spontaneous abortion, stillbirth, perinatal death
Time frame: At enrollment, 24-28 weeks, 32-34 weeks of gestation, delivery, and 42 days postpartum
Maternal death
Deaths during pregnancy or less than 42 days after termination of pregnancy.
Time frame: At 24-28 weeks, 32-34 weeks of gestation, delivery, and 42 days postpartum
The rate of cesarean delivery
Cesarean rate is defined as the number of cesarean delivery divided by the number of live births.
Time frame: At delivery
Gestational duration
The number of weeks from the first day of the woman's last recorded menstrual period to the day of delivery deaths occurring within 28 days.
Time frame: At enrollment, delivery
Birth weight
Every newborn's weight will be measured twice, but if the difference between the two measurement results is more than 0.1 kg, it will be measured for the third time, Low birth weight was defined as birth weight \<2500 g.
Time frame: At delivery
Birth length
Every newborn's length will be measured twice, but if the difference between the two measurement results is more than 0.1 kg, it will be measured for the third time.
Time frame: At delivery
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