Chronic Obstructive Pulmonary Disease (COPD) patients are more likely to develop acute hypercapnic respiratory failure. In the acute phase, non invasive ventilation has been shown to improve mortality and reduce intubation rate. Few studies are available about long term benefits of home non invasive ventilation in COPD patients with chronic hypercapnic respiratory failure who survived after an acute episode. The purpose of this study is to determine whether home non invasive ventilation can reduce recurrent acute hypercapnic respiratory failure in COPD patients who survived an acute hypercapnic respiratory failure episode treated by non invasive ventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
86
CH Dieppe
Dieppe, France
RECRUITINGCH Elbeuf
Elbeuf, France
RECRUITINGLe Havre, Jacques Monod Hospital
Montivilliers, France
RECRUITINGCHU de Rouen
Rouen, France
RECRUITINGacute hypercapnic respiratory failure episode
first episode of acute hypercapnic respiratory failure episode requiring hospitalization
Time frame: up to 24 months
acute hypercapnic respiratory failure episode rate
Time frame: up to 24 months
pulmonary function test
Time frame: at one month and every six months up to 24 months
Six Minute Walk Distance
Time frame: at one month and every six months up to 24 months
Quality of life
Time frame: at one month and every six months up to 24 months
Heart function
left and right heart function assessed using echocardiography
Time frame: at one month and every six months up to 24 months
Cost effectiveness
Time frame: at one month and every six months up to 24 months
mortality
Time frame: at one month and every six months up to 24 months
arterial blood gas
Time frame: at one month and every six months up to 24 months
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