This study examine the effects of very low carbohydrate diet (in which the calories requirements are mostly from fat) to the level of systemic inflammation (measured by Glasgow Prognostic Score), serum lactate and TNF Alpha levels
This study examine the effects of very low carbohydrate diet (in which the calories requirements are mostly from fat) to the level of systemic inflammation (measured by Glasgow Prognostic Score), serum lactate and TNF Alpha levels. The subjects are colorectal adenocarcinoma patients who were decided by experts to be managed by best supportive care. These patients are not deemed to be suitable for surgical intervention , chemotherapy or radiotherapy anymore. The main treatment is supportive. We would like to examined the effect of very low carbohydrate diet on these patients, in which theoretically tumtor cells of the colorectal adenocarcinoma needed glucose to replicate and increases the systemic inflammation response.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
26
1 : 4 ratio of carbohydrate to fat of the total daily calories intake
Glasgow Prognostic Score
A score to evaluate systemic inflammation response
Time frame: Change of baseline Glasgow Prognostic Score on day 21
Serum Lactate
Lactate level in blood serum
Time frame: Change of baseline Serum Lactate on day 21
TNF Alpha
Level of Tumor Necrosis Factor Alpha in the blood serum
Time frame: Change of baseline TNF Alpha serum level on day 21
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