Prevention of Microvascular Complications in Prediabetes e-PREDICE Study

Inclusion criteria * Impaired Fasting Glucose (IFG): Fasting Plasma Glucose (FPG) 6.1 to 6.9mmol/l and 2-hour Plasma Glucose (2-h PG): \<7.8mmol/L; * Impaired Glucose Tolerance (IGT): FPG \<7.0mmol/L and 2h PG \>\_7.8 and \<11.1 mmol/L -Informed consent given Exclusion Criteria: * Type 1 diabetes (T1D) * known or screen-detected Type 2 diabetes (T2D). * Use of any anti-diabetic drug within the 3 months prior to inclusion. * Previous cardiovascular event, stroke or revascularization procedure of any arterial territory * Morbid obesity (BMI\>45) * Current renal replacement therapy. * Renal function impairment: GFR \<60 ml/min/1.73m2. * Previous diagnosis of liver cirrhosis or chronic hepatitis * Elevation of liver enzymes (AST/AST) \>3 times of the upper normal ranges\*\* (6m or BL). * Previous diagnosis of acute or chronic pancreatitis * Elevation of pancreatic enzymes (Amylase/Lipase) \>3 times of the upper normal ranges (6m or BL). * Previous diagnosis of Chronic Heart Failure (NYHA class III or higher). * Organ transplant or waiting for organ transplant. * Diagnosis of malignant neoplasm requiring chemotherapy, surgery, radiation or palliative therapy in the previous 5 years. * End-stage or metastatic cancer. * Known or suspected hypersensitivity to trial products or related products. * Known use of non prescribed narcotics or illicit drugs. * Simultaneous participation in any other clinical trial of an investigational agent. * Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant. * Cataract that impedes the retinal evaluation of both eyes. * Ocular surgery planned in the next 6 months * Concomitant intraocular treatment (retina or choroid). * Tropicamide allergy * Participants with screen retinogram not optimal for retinal assessment * Complete amputation of one/ both hands or one/both feet. * Dementia, mental disorder or evident cognitive impairment unable to give informed consent. * Institutionalization (nursing/mental health home, hospital, prison, etc). * Suspected renal artery stenosis Recent gastrointestinal bleeding (within the last year) * Any circumstance where ongoing medication might lead to potential adverse drug effect. * Any other acute condition or exacerbation of chronic condition that in the investigator's opinion would interfere with the trial initiation or visit schedules or procedures.