To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.
Dietary triglycerides are hydrolyzed during digestion to two fatty acids and one 2-monoacyl glycerol. The study will investigate the effects of these different fat components on gut hormone secretion in gastric bypass operated patients and non-operated BMI-matched controls.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
20
Ingestion of 13.15 g C-8 dietary oil providing 0.0216 mol of triglycerides.
Ingestion of 10.17 g tricaprylin providing 0.0216 mol of triglycerides.
Ingestion of 19 g olive oil providing 0.0216 mol of triglycerides.
Dept. of Endocrinology
Hvidovre, Denmark
Within group difference in glucagon-like peptide-1 (GLP-1) secretion (evaluated by AUC above basal).
Comparison of the GLP-1 responses (evaluated by AUC above basal) induced by the different oils.
Time frame: 0-240 min following fat ingestion.
Within group difference in Gastric Inhibitory Peptide (GIP) secretion (evaluated by AUC above basal).
Comparison of the GIP responses (evaluated by AUC above basal) induced by the different oils.
Time frame: 0-240 min following fat ingestion.
Within group difference in cholecystokinin (CCK) secretion (evaluated by AUC above basal).
Comparison of the CCK responses (evaluated by AUC above basal) induced by the different oils.
Time frame: 0-240 min following fat ingestion.
Between group comparison of GLP-1 secretion (evaluated by AUC above basal).
GLP-1 secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils.
Time frame: 0-240 min following fat ingestion.
Between group comparison of GIP secretion (evaluated by AUC above basal).
GIP secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils.
Time frame: 0-240 min following fat ingestion.
Between group comparison of CCK secretion (evaluated by AUC above basal).
GIP secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils.
Time frame: 0-240 min following fat ingestion.
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Responses (evaluated by AUC above basal) of insulin within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of C-peptide within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of peptide YY (PYY) within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of oxyntomodulin within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of glucagon within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of bile acids within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of fibroblast growth factor 19 (FGF-19) within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of lipid metabolites (triglyceride, cholesterol, fatty acids) within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of neurotensin within and between groups.
Time frame: 0-240 min following fat ingestion.
Responses (evaluated by AUC above basal) of glucose within and between groups.
Time frame: 0-240 min following fat ingestion.
Between group comparison of differences in GLP-1 secretion (evaluated by AUC above basal).
Differences in GLP-1 secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects.
Time frame: 0-240 min following fat ingestion.
Between group comparison of differences in GIP secretion (evaluated by AUC above basal).
Differences in GIP secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects.
Time frame: 0-240 min following fat ingestion.
Between group comparison of differences in CCK secretion (evaluated by AUC above basal).
Differences in CCK secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects.
Time frame: 0-240 min following fat ingestion.