Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy

Overview

PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation.

Prophylactic ICD implantation was recently found to be non-beneficial over usual clinical care in non-ischemic systolic heart failure (LVEF≤35%) and 60-70% percent of SCD cases even occur in individuals with LEVF\>35%. A growing evidence, that emphasizes the urgent need to improve the prediction of sudden cardiac death (SCD) in dilated cardiomyopathy (DCM). CMR provides unique information on myocardial mechanics, fibrotic burden, inflammation and microvascular dysfunction, thereby allowing to quantify key substrates for myocardial arrhythmogenic potential. PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation. Acquired candidate predictors are among others: * Global and regional T1/T2 * T1/T2 inhomogeneity * Extracellular volume fraction * Microvascular dysfunction * LA function and filling fraction * Global and regional circumferential, radial or longitudinal myocardial strain * Biomarkers

Conditions

Interventions

Eligibility

Locations (2)

Outcomes

Central Contacts