We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc. We will establish a large sample of blood, urine, adrenal tissue of the subjects, and the genomics,metabonomics, proteomics database, to explore the mechanism of the PA and target organ damage, risk factors, diagnostic methods and biomarkers.
This study will include the subjects of a series of studies on hypertension conducted by our team, including essential hypertension, PA subjects, and establish a large sample database and specimen bank through follow-up and omics analysis.
Study Type
OBSERVATIONAL
Enrollment
1,500
no intervention
Qifu Li
Chongqing, Chongqing Municipality, China
RECRUITINGnumbers of patients who develop cardiovascular events
compare the long-term cardiovascular and cerebrovascular events in patients with primary aldosteronism and essential hypertension
Time frame: 1-15 years
estimated glomerular filtration rate (eGFR)
Compare the incidence of hypertensive nephropathy between two groups (based on eGFR)
Time frame: 1-15 years
The incidence of new atrial fibrillation
Compare the occurrence of new atrial fibrillation between patients with primary aldosteronism and essential hypertension
Time frame: 1-15 years
The incidence of left ventricular hypertrophy
Compare the occurrence of left ventricular hypertrophy between patients with primary aldosteronism and essential hypertension
Time frame: 1-15 years
the variation of carotid intima-media thickness
Compare the occurrence of the variation of carotid intima-media thickness between patients with primary aldosteronism and essential hypertension
Time frame: 1-15 years
subgroup analysis of cardiovascular events
Compare the cardiovascular and cerebrovascular risk between unilateral PA and idiopathic bilateral adrenal hyperplasia
Time frame: 1-15 years
quality of life score
Compare the quality of life between unilateral PA and idiopathic bilateral adrenal hyperplasia by the questionnaire.
Time frame: 1-15 years
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Cardiovascular risk score
To investigate what kind of cardiovascular risk score can better predict cardiovascular risk of PA
Time frame: 1-15 years