Acute Pain Memory Among Former Burned: Exploration of fMRI.

Centre Hospitalier Universitaire de Saint Etienne24 enrolled

Overview

Pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. That's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain. Certain situations bring to relive pain sensation. Investigators were interested to former burned. They wonder about somatic memory and unconscious of acute.

It is a comparative and monocentric study. There are two groups. On the one hand, there is the former burned and, on the other hand, healthy volunteers. While they thought to painful memory or not, functional Magnetic Resonance Imaging (fMRI) will be performed. Then, investigators compare two functional Magnetic Resonance Imaging (fMRI). Main objective of this study is link up between brain activity by functional Magnetic Resonance Imaging (fMRI) and acute pain memory.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Magnetic Resonance Imaging Neuronal Activity

Interventions

fMRIOTHER

During fMRI, patients and control group will have to thought to seven painful memories, seven emotional memories not painful, seven neutral memories. At every memory there is control test. It is to count backwards.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: For control group: * Affiliated or entitled to a social security * Have signed consent before their participation in the study * Adult women and men french and is right handed * Vision and hearing normal or corrected For former burned: * Affiliated or entitled to a social security * Have signed consent before their participation in the study * Adult women and men french and is right handed * Vision and hearing normal or corrected * Localized burn at the hand or feet onset between 12 and 24 years * Not sequelae painful at the inclusion * Scope and depth of the burn according to classifications CIM 10 Exclusion Criteria: For control group: * Any contraindications to pass an fMRI test * Neuropathic pains and psychiatric disorders * Medical history of head injuries * Burn presence For former burned: * Any contraindications to pass an fMRI test * Neuropathic pains and psychiatric disorders * Medical history of head injuries

Locations (1)

CHU de Saint-Etienne

Saint-Etienne, France

Outcomes

Primary Outcomes

BOLD (blood-oxygen-level dependent) signal between painful memories

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Time frame: Months 3

BOLD (blood-oxygen-level dependent) signal between emotional memories not painful

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Time frame: Months 3

BOLD (blood-oxygen-level dependent) signal between neutral memories

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Time frame: Months 3

BOLD (blood-oxygen-level dependent) signal between control test.

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Time frame: Months 3

Secondary Outcomes

BOLD (blood-oxygen-level dependent) signal between control group for every conditions

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Time frame: Months 3

BOLD (blood-oxygen-level dependent) signal between patients for every conditions

Correlation between BOLD measured by functional Magnetic Resonance Imaging (fMRI) and groups for every conditions: painful memories, emotional memories not painful, neutral memories and control test.

Data from ClinicalTrials.gov

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