Vaccination With Dendritic Cells Pulsed With Autologous Tumor Homogenate in Combination With HD-IL2 and Immunomodulating Radiotherapy in Metastatic RCC

Inclusion Criteria: 1. Signed Written Informed Consent: patients must be willing and able to give written informed consent, that have to be given before starting of screening procedure. 2. Availability of autologous tumor tissue fulfilling acceptance criteria prescribed by the "Product Specification File". 3. Patients must have histologically or cytologically confirmed RCC (all histology types except for urothelial cancer); 4. Patients must have stage IV disease in progression after at least 1 TKI and/or antiangiogenetic and/or mTOR inhibitors therapy (patients must have finished prior treatments at least 4 weeks before the first IL2 dose) 5. Patients must have at least one measurable lesion, according to the irRC response criteria (see section 8 ), after asportation of tumor tissue for vaccine preparation. The tumor lesions that will be irradiated are excluded for response evaluation. 6. Life expectancy of greater than 3 months. 7. ECOG performance status 0-1 8. Patients must have organ and marrow function as defined below: * leukocytes \>4000/µL * absolute neutrophil count \>1,500/µL * platelets \>100,000/µL * total bilirubin within normal institutional limits * AST(SGOT)/ALT(SGPT) \<2.5 X institutional upper limit of normal * creatinine \< 1.5 mg/dl * haemoglobin \>8.0 gm/dl * hematocrit \<30% 9. ECG and echocardiogram within normal institutional limits 10. Pulmonary function tests within normal institutional limits (to be performed only in patients with lung metastases or history of impaired lung function) 11. No contraindication for the use of vasopressor agents 12. Negative screening tests for HIV, HBV HCV and syphilis not older than 30 days before performing any of the GMP-regulated activities required (leukapheresis, collection of tumor biopsies to be used for tumor homogenate preparation); 13. Men and women aged \> 18 years. 14. Women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout the study and for up 8 weeks after the study, in order to minimize the risk of pregnancy; 15. Patients must have normal organ and marrow function according to clinical practice. Exclusion Criteria: 1. Patients who have positive tests to HCV, HBV, HIV, or syphilis (specific blood testing must be performed within 30 days before any GMP-regulated activity (leukapheresis and collection of tumor biopsies to be used for tumor homogenate preparation). 2. Patients who did not have prior lines of systemic therapy for advanced disease. 3. Participation in another clinical trial with any investigational agents within 30 days prior to study screening. 4. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements (on physician's judgment). 5. Other known malignant neoplastic diseases in the patient's medical history with a disease-free interval of less than 3 years (except for previously treated basal cell carcinoma and in situ carcinoma of the uterine cervix); 6. Patients who have had chemotherapy or radiotherapy or immunotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier. 7. Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. 8. History of allergic reactions attributed to compounds of similar chemical or biologic composition to IL-2 or other agents used in the study. 9. Any autoimmune disease which could be exacerbated by IL-2 10. A medical illness requiring chronic treatments with corticosteroids or other immunosuppressive agents 11. A history of significant cardiovascular disease, including myocardial infarction, congestive heart failure, primary cardiac arrhythmias, angina pectoris or cerebrovascular accident 12. HIV-positivity, whether or not symptomatic 13. Any contraindication to undergo leukapheresis as evaluated by transfusionist (e.g. severe anemia, piastrinopenia, oral anticoagulant therapy) or to undergo surgery.