Evaluation of the Efficacy and Safety of S-amlodipine+Chlorthalidone Combination Therapy and S-amlodipine+Telmisartan Combination Therapy in Hypertensive Patients Inadequately Controlled With CCB(Calcium Channel Blocker) Monotherapy
The aim of this study is to verify the difference at week 12 from the baseline value in the average variation of diastolic blood pressure (sitDBP) of the study group in which S-amlodipine / Chlorthalidone combination therapy is to be used in patients with essential hypertension who did not adequately respond to monotherapy of amlodipine or S-amlodipine, compared to the control group, in which a combination therapy of S-amlodipine / telmisartan is to be used.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
170
patients will receive S-amlodipine 2.5mg + Chlorthalidone 25mg p.o. once a day for 12 weeks.
patients will receive S-amlodipine 2.5mg + Telmisartan 40mg p.o. once a day for 12 weeks.
Hallym University Medical Center
Anyang, Dongan-gu, South Korea
RECRUITINGKyung Hee University Hospital
Seoul, Dongdaemun-gu, South Korea
RECRUITINGsit diastolic blood pressure
Mean change in sit diastolic blood pressure after 12 weeks compared to baseline.
Time frame: 12 weeks
sit diastolic blood pressure
Mean change in sit diastolic blood pressure after 6 weeks compared to baseline.
Time frame: 6 weeks
sit systolic blood pressure
Mean change in sit systolic blood pressure after 6 weeks and 12 weeks compared to baseline.
Time frame: 12 weeks
Blood pressure normalization
Blood pressure normalization ratio after 12 weeks compared to baseline( sit systolic blood pressure \<140 mmHg or sit diastolic blood pressure \<90 mmHg).
Time frame: 12 weeks
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Hallym University Medical Center
Seoul, Gangdong-gu,, South Korea
RECRUITINGSamsung Medical Center
Seoul, Gangnam-Gu, South Korea
RECRUITINGKorea Univ. Guro Hospital
Seoul, Guro, South Korea
RECRUITINGSeoul National University Hospital
Seoul, Jongno-gu, South Korea
RECRUITINGHanyang University Medical Center
Seoul, Seongdong-gu, South Korea
RECRUITINGAsan Medical Center
Seoul, Songpa-gu, South Korea
RECRUITINGAjou Univ. Medical Center
Suwon, Yeong-tong, South Korea
RECRUITINGSeoul National University Bundang Hospital
Seongnam, South Korea
RECRUITING