Study of Targeted Therapy Using Transcription Activator-like Effector Nucleases in Cervical Precancerous Lesions

Inclusion Criteria: * Documented HPV16 infection and integration. * Married and fertile, no fertility requirements. * The cervical transformation zone was type I or II, and the biopsy results under colposcopy suggested SIL. * Without administration of hormone in the last six months * Subjects must be meet the ethical requirements and have signed informed consent Exclusion Criteria: * Pregnancy and breast feeding * Any bacterial vaginitis * Any Fungal vaginitis * Any sexually transmitted diseases * Active drug or alcohol abuse * Any HPV medications within the past 12 weeks * Allergy to active or non active ingredients in the study of drugs * Cardiac insufficiency * Liver and renal insufficiency * Hypertension and severe complications * Serious illness in past 30 days * Currently participating in another clinical trial or any prior gene therapy