DNA Methylation and 1-C Metabolism Nutrient Intake

Cancer Council Victoria5,983 enrolled

Overview

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays. The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Study Type

OBSERVATIONAL

Enrollment

5,983

Conditions

DNA Methylation

Eligibility

Sex: ALLMin age: 27 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study * Completed a 121-item Food Frequency Questionnaire * Had a blood DNA sample with a measure of methylation Exclusion Criteria: * Missing data in any of the outcome, exposure, or confounders (N=797 excluded)

Outcomes

Primary Outcomes

Blood DNA methylation

Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay

Time frame: 2014-2015

Secondary Outcomes

Blood DNA methylation

Methylation of DNA from peripheral blood, LINE-1, Alu, Sat2

Time frame: 2014-2015

Data from ClinicalTrials.gov

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