Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode

Centre Hospitalier Universitaire de Besancon42 enrolled

Overview

The study focuses on the identification of clinical, physiological and morphological markers that could predict the response to antidepressant in elderly suffering from unipolar depressive disorder.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Unipolar Depression

Interventions

Neuropsychological evaluationsOTHER

Neuropsychological evaluations including oral fluency, performed specifically for the study

Psychiatric interviewOTHER

Cardiovascular risk assessmentOTHER

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Depressive episode according to DSM-5 criteria * Unipolar depression * MADRS ≥ 20 * Antidepressive treatment (Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors) Exclusion Criteria: * Other comorbid mental disorders (bipolar disorder, schizophrenia, recent addiction \< 3 months except for tobacco) * Depression with psychotic features * Serious unstabilized somatic illness * Protected persons * Dementia suspected at the time of enrollment

Locations (1)

Centre Hospitalier Universitaire de Besançon

Besançon, France

RECRUITING

Outcomes

Primary Outcomes

Ability of the verbal fluency test score to predict the response to antidepressive treatment

verbal fluency is assessed during the neuropsychological assessment

Time frame: week 10

Central Contacts

Julie Monnin, PhD

CONTACT

jmonnin@chu-besancon.fr

Data from ClinicalTrials.gov

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