Asphyxia at Birth : Causes and Neonatal Outcome

Hospices Civils de Lyon61,448 enrolled

Overview

This is an historic cohort study based on the birth and delivery register of the HFME maternity ward. This study aim at understanding the evolution of asphyxia at birth, at all gestational ages, identifying causes and describing neonatal outcomes since 2000, when a second line strategy for foetal surveillance (fetal ECG) and systematic umbilical acid-gas cord blood were introduced in our maternity ward. The investigator's hypothesis was that the neonatal asphyxia decrease could be due to 3 main factors including second line strategy introduction, systematic umbilical cord acid-base implementation and improvement in antenatal risk factor screening for asphyxia. The investigator's second hypothesis was that neonatal prognosis in neonates with acidosis was improved with systematic early after birth EEG evaluation, allowing early treatment and surveillance.

Study Type

OBSERVATIONAL

Enrollment

61,448

Conditions

Neonatal Asphyxia

Eligibility

Sex: ALLMax age: 1 Hour

Medical Language ↔ Plain English

Inclusion Criteria: * All births at the maternity ward of the hospital Femme-Mère-Enfant from 1st of january 2000 to 31 december 2016 Exclusion Criteria: * Infants born after medical pregnancy termination and born out of the hospital and secondarily hospitalized in our department will be excluded

Locations (1)

Department of obstetrics, Femme Mère Enfant Hospital

Outcomes

Primary Outcomes

Rate of Neonatal asphyxia

Neonatal asphyxia define as fetal death, neonatal death, NICU transfer, neonatal seizure, umbilical-artery blood pH ≤ 7.05 with a base deficit ≥ 12 mmol per liter, intubation for ventilation at delivery or neonatal encephalopathy

Time frame: 2 months