The Effect of Transcranial Direct Current Stimulation (tDCS) on Depression in PD

Inje University26 enrolled

Overview

Depression is common in Parkinson's disease (PD), but the effective treatment is not established yet. tDCS is a non-invasive brain stimulation to modulate brain function. The tDCS on the depression in general population were already conducted, but not in PD. This study is to know whether transcranial direct current stimulation (tDCS) is effective for the treatment of depression in PD. Participant will be asked to visit three consecutive days for the non-invasive stimulation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Parkinson's Disease

Interventions

transcranial direct current stimulation (tDCS)DEVICE

tDCS is one of non-invasive brain stimulation. Constant, low current is delivered to the specific brain areas to change brain plasticity.

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * UK Parkinson's disease brain bank criteria * more than 19 years old * Able to provide consent for the protocol * Depression (based on DSM-IV criteria) Exclusion Criteria: * Dementia * Unpredictable symptom fluctuations * Contraindication to tDCS (i) irritations, cuts, lesions in the brain (ii) any preexisting unstable medical conditions, or conditions that may increase the risk of stimulation such as uncontrolled epilepsy (iii) history of severe cranial trauma with alteration of the cranial anatomy or metallic intracranial implants (iv) history of seizure * Subjects without the capacity to give informed consent * If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension

Locations (1)

Inje university, Busan Paik Hospital

Busan, South Korea

RECRUITING

Outcomes

Primary Outcomes

BDI score

The changes of Beck depression inventory after tDCS

Time frame: (1) before the1st visit (within one month) (2) right after the 3rd tDCS (3) within one months after the 3rd tDCS

Secondary Outcomes

HDRS score

The changes of Hamilton Depression Rating Scale after tDCS

Time frame: (1) before the 1st visit (within one month) (2) right after 3rd tDCS, within 24 hours (3) within one months after the 3rd tDCS

MADRS score

The changes of Mongomery-Asberg Depression Rating Scale after tDCS

Time frame: (1) before the 1st visit (within one month) (2) right after the 3rd tDCS, within 24 hours (3) within one months after 3rd tDCS

resting state functional MRI

The changes of resting state functional MRI after tDCS

Time frame: (1) before the 1st visit (within one month) (2) after the 3rd tDCS, within 24 hours (on the same day as the 3rd tDCS)

Central Contacts

Sang Jin Kim, MD, PhD

CONTACT

82-51-890-8954 jsk120@hanmail.net

Data from ClinicalTrials.gov

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