Patterns of Neurocircuitry Activation In Severe Asthma

Inclusion Criteria: * Currently enrolled in Severe Asthma Research Program III (2012-0571) study * Has severe asthma * Is a male or female with no health concerns that might affect the outcome of the study * Provided a negative urine pregnancy test prior to visit (Females only) * Capable and willing to grant written informed consent and cooperate with study procedures and requirements (investigator discretion) * Is able to tolerate a simulated functional Magnetic Resonance Imaging brain scanning session * Is able to give valid informed consent to participate by signing and dating a written consent form Exclusion Criteria: * Uses psychotropic medication that might affect function of neurocircuitry implicated in our hypotheses (at the discretion of a study physician or Co-Investigator) * Has one or more contraindications for functional Magnetic Resonance Imaging * Has needle phobia or claustrophobia * Unable to distinguish specific colors used in Stroop task * History of a diagnosed Bipolar Disorder, Schizophrenia, or Schizoaffective Disorder * Is a pregnant or lactating female * Has had an upper or lower respiratory infection within 1 month of the visit * Has unstable asthma as indicated by self-report of increased symptoms or increased beta-agonist use over the 2 weeks preceding the visit * Is a current smoker (defined as smoked within the last year) or a former smoker with a history of \>5 pack years * Any condition which, in the opinion of the investigator, might interfere with participation in the study * Inability or unwillingness to perform required study procedures